Differential CRX and OTX2 expression in human retina and retinoblastoma
نویسندگان
چکیده
منابع مشابه
Derivation of human differential photoreceptor cells from adult human dermal fibroblasts by defined combinations of CRX, RAX, OTX2 and NEUROD
Redirecting differentiation of somatic cells by over-expression of transcription factors is a promising approach for regenerative medicine, elucidation of pathogenesis and development of new therapies. We have previously defined a transcription factor combination, that is, CRX, RAX and NEUROD, that can generate photosensitive photoreceptor cells from human iris cells. Here, we show that human d...
متن کاملDifferential gene expression profile of retinoblastoma compared to normal retina
PURPOSE The retinoblastoma gene (RB1) is a tumor suppressor gene that was first discovered in a rare ocular pediatric tumor called retinoblastoma (RB). The RB1 gene is essential for normal progression through the cell cycle and exerts part of its function through the family of transcription factors (E2F) and many other intermediaries. In the absence of normal RB1, genomic instability and chromo...
متن کاملThe effect of retinoids and butyrate on the expression of CRX and IRBP in retinoblastoma cells
We sought to determine whether differentiation agents such as retinoids and butyrate regulate transcript levels of interphotoreceptor retinoid binding protein (IRBP) and cone rod homeobox (CRX), a homeodomain transcription factor that regulates IRBP promoter activity. WERI-Rb1 retinoblastoma cells were treated with all-trans retinol, all-trans retinoic acid, or butyrate. IRBP and CRX mRNA level...
متن کامل03-P127 Functional redundancy and difference of Otx2 and Crx transcription factors in retinal photoreceptor development
ted embryo. Using the example of a Forkhead binding site, we will show that this approach allows detection of very limited changes in enhancer activity in a whole embryo and, in particular, makes possible the identification of repressor binding sites that are usually difficult to detect. We will also discuss the possible implications of the presence of this Forkhead repressor binding site on hi...
متن کاملCharacterization of some glycolytic enzymes from human retina and retinoblastoma.
GLycolytic enzymes were studied from normal human retinas (both fetal and adult) and from retinoblastomas of eight patients and an established retinoblastoma cell line. No significant differences were found between the enzyme activities in the tissues investigated except for hexokinase and pyruvate kinase, which were significantly decreased in the tumor cells. In fetal retina, five different fo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2009
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.2009.06322.x